About oesophageal or GEJ cancer

Is it time to re-evaluate your treatment approach?

Why combine chemotherapy with immunotherapy?

The goal of combining systemic therapies is to take advantage of the unique mechanism of action of each agent to achieve antitumor activity. 7.8

Combining therapies with complementary modes of actions may improve antitumor activity7,8

Learn more about combining immunotherapy with chemotherapy in the treatment of advanced Oesophageal and GEJ cancers

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 References

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2. Arnold M, Abnet CC, Neale RE, et al. Global burden of 5 major types of gastrointestinal cancer. Gastroenterology. 2020;159(1):335-349
3. American Cancer Society. Esophagus cancer early detection, diagnosis, and staging. Accessed March 1, 2022. https://www.cancer.org/content/dam/CRC/PDF/Public/8615.00.pdf
4. Shah, MA. Update on metastatic gastric and Oesophageal cancers. J Clin Oncol. 2015;33(16):1760–1769. 
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6. Sun JM, Shen L, Shah MA, et al. Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced Oesophageal cancer (KEYNOTE-590): a randomized, placebo-controlled, phase 3 study. Lancet. 2021;398:759–771.
7. Kersten K, Salvagno C, de Visser KE. Exploiting the immunomodulatory properties of chemotherapeutic drugs to improve the success of cancer immunotherapy. Front Immunol. 2015;6(516). doi:10.3389/fimmu.2015.00516 
8. Emens LA, Middleton G. The interplay of immunotherapy and chemotherapy: harnessing potential synergies. Cancer Immunol Res. 2015;3(5):436–443. doi:10.1158/2326-6066.CIR-15-0064 
9. National Cancer Institute. Dictionary of cancer terms. Accessed March 1, 2022. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/immunotherapy
10. American Cancer Society. Treating esophagus cancer. Accessed March 1, 2022. https://www.cancer.org/content/dam/CRC/PDF/Public/8617.00.pdf
11. American Cancer Society. How chemotherapy drugs work. Accessed February 10, 2022. https://www.cancer.org/content/dam/CRC/PDF/Public/8418.00.pdf
12. Marieb EN, Hoehn K. Chapter 3: Cells: the living units. In: Human Anatomy & Physiology. 11th ed. Pearson; 2019:60–114.